|
KMID : 0829220110350030153
|
|
Korean Journal of Oral and Maxillofacial Pathology
2011 Volume.35 No. 3 p.153 ~ p.160
|
|
|
Expression of α5 Integrin in Hypoxic Oral Cancer Cells is Regulated via Phosphoinositide 3-kinase/Akt Pathway
|
|
Park Jeong Hee
Park Ji-Eun
Woo Vok-Hee
Park Bong-Soo
Chung Jin
Ryu Mi-Heon
Park Hae-Ryoun
|
|
|
Abstract
|
|
|
|
Cancer cells are often found in an ischemic condition due to the rapid outgrowth of their vascular supply, and these cells are expected to develop an increased potential for local invasive growth. Since the first steps are characterized by increased motility and invasiveness, expression of molecules involved in cellular adhesion to extracellular matrix (ECM) is increased in the process of cancer cell invasion and metastasis. In this work we explored the molecular characteristics and its regulatory mechanism of hypoxic oral squamous cell carcinoma (OSCC) cells. Our experiment identified that hypoxia increases α5 integrin protein levels through phosphoinositide 3-kinase (PI3K)/Akt pathway in OSCC cells.
|
|
|
KEYWORD
|
|
|
Akt, Hypoxia, Oral squamous cell carcinoma, PI3K, α5 integrin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|